Basic CYP time-dependent inhibition risk table
basic_cyp_tdi_risk_table.RdBasic CYP time-dependent inhibition risk table
Usage
basic_cyp_tdi_risk_table(
perp,
cyp_tdi,
cyp_kdeg = cyp_turnover,
na.rm = TRUE,
show_dose = FALSE
)Arguments
- perp
The perpetrator object.
- cyp_tdi
The CYP TDI data as data frame. The following fields are expected:
'name' The perpetrator compound name as character.
'cyp' The CYP enzyme as character.
'ki' The \(K_I\) in \(\mu M\) as numeric.
'kinact' The \(k_{inact}\) in 1/h as numeric.
'source' Optional source information as character,
- cyp_kdeg
The CYP turnover data as data frame. Defaults to the built-in reference data, cyp_turnover.
- na.rm
Switch to define whether rows with lacking \(K_i\) data are removed from the output. Defaults to
FALSE.- show_dose
Show perpetrator dose in table title, defaults to
FALSE.
Examples
basic_cyp_tdi_risk_table(examplinib_parent, examplinib_cyp_tdi_data)
#>
#>
#> Table: Risk for CYP TDI by examplinib, basic model
#>
#> |CYP | $K_{I}$ ($\mu M$)| $f_u$| $k_{inact}$ (1/h)| $k_{deg}$ (1/h)|source | $R$|risk |
#> |:------|-----------------:|-----:|-----------------:|---------------:|:---------|----:|:----|
#> |CYP3A4 | 0.17| 0.02| 0.04| 0.02|study 001 | 2.72|Yes |
basic_cyp_tdi_risk_table(examplinib_compounds, examplinib_cyp_tdi_data)
#>
#>
#> Table: Risk for CYP TDI by examplinib, basic model
#>
#> |CYP | $K_{I}$ ($\mu M$)| $f_u$| $k_{inact}$ (1/h)| $k_{deg}$ (1/h)|source | $R$|risk |
#> |:------|-----------------:|-----:|-----------------:|---------------:|:---------|----:|:----|
#> |CYP3A4 | 0.17| 0.02| 0.04| 0.02|study 001 | 2.72|Yes |
basic_cyp_tdi_risk_table(examplinib_compounds, examplinib_cyp_tdi_data,
show_dose = TRUE)
#>
#>
#> Table: Risk for CYP TDI by examplinib (450 mg), basic model
#>
#> |CYP | $K_{I}$ ($\mu M$)| $f_u$| $k_{inact}$ (1/h)| $k_{deg}$ (1/h)|source | $R$|risk |
#> |:------|-----------------:|-----:|-----------------:|---------------:|:---------|----:|:----|
#> |CYP3A4 | 0.17| 0.02| 0.04| 0.02|study 001 | 2.72|Yes |