CYP time-dependent inhibition risk

CYP time-dependent inhibition risk

Usage

basic_cyp_tdi_risk(perp, cyp_tdi, cyp_kdeg = cyp_turnover)

Arguments

perp

Precipitant object.

cyp_tdi

inhibition_data object.

cyp_kdeg

CYP turnover rates as data frame, defaults to cyp_turnover.

Value

DDI risk object.

Examples

basic_cyp_tdi_risk(examplinib, examplinib_cyp_tdi)
#> ──────── Clinical DDI risk assessment ──────── 
#> Time-dependent CYP inhibition risk for examplinib 
#> 
#> object   ki     fu      kinact   kdeg     source      r      risk   
#> CYP3A4   0.17   0.023   0.04     0.0193   study 001   2.72   TRUE