Skip to contents

Non-compartmental analysis of NIF data

Source: R/nif_nca.R
nca.Rd

[Experimental]

Usage

nca(
  nif,
  analyte = NULL,
  parent = NULL,
  keep = NULL,
  group = NULL,
  time = "TIME",
  duplicates = "stop",
  duplicate_function = mean,
  silent = NULL
)

Arguments

nif

A nif object.

analyte

The analyte as character.

parent

The parent as character.

keep

Columns to keep, as character.

group

Columns to group by, as character.

time

The time field as character.

duplicates

Selection how to deal with duplicate observations with respect to the USUBJID, ANALYTE and DTC fields:

  • 'stop': Stop execution and produce error message

  • 'identify': Return a list of duplicate entries

  • 'resolve': Resolve duplicates, applying the duplicate_function to the duplicate entries.

duplicate_function

Function to resolve duplicate values, defaults to mean.

silent

Suppress messages.

Value

A data frame.

Details

This function is a wrapper around the NCA functions provided by the PKNCA package.

NA values are set to zero! Negative concentrations are set to zero!

Examples

head(nca(examplinib_sad_nif, time = "TAD"))
#> ! No analyte specified for NCA!
#> Selected RS2023 as the most likely analyte!
#> ℹ Parent set to RS2023
#>   ID DI start end  PPTESTCD      PPORRES exclude DOSE
#> 1  1  1     0  24   auclast 135.83589639    <NA>    5
#> 2  1  1     0 Inf      cmax  48.55300000    <NA>    5
#> 3  1  1     0 Inf      tmax   1.00000000    <NA>    5
#> 4  1  1     0 Inf     tlast  96.00000000    <NA>    5
#> 5  1  1     0 Inf clast.obs   0.00020000    <NA>    5
#> 6  1  1     0 Inf  lambda.z   0.08606345    <NA>    5
head(nca(examplinib_fe_nif, time = "TIME", group = "FASTED"))
#> ! No analyte specified for NCA!
#> Selected RS2023 as the most likely analyte!
#> ℹ Parent set to RS2023
#> ! 5 negative concentrations set to zero!
#> ℹ NCA: Group by FASTED
#>   FASTED ID DI start end  PPTESTCD      PPORRES exclude DOSE
#> 1      1  1  1     0  24   auclast 2.504642e+04    <NA>  500
#> 2      1  1  1     0 Inf      cmax 6.325101e+03    <NA>  500
#> 3      1  1  1     0 Inf      tmax 1.000000e+00    <NA>  500
#> 4      1  1  1     0 Inf     tlast 1.680000e+02    <NA>  500
#> 5      1  1  1     0 Inf clast.obs 9.704197e-05    <NA>  500
#> 6      1  1  1     0 Inf  lambda.z 8.895551e-02    <NA>  500