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This function is a wrapper around the NCA functions provided by the PKNCA package.

Usage

nca(
  obj,
  analyte = NULL,
  parent = NULL,
  keep = "DOSE",
  group = NULL,
  nominal_time = FALSE,
  average_duplicates = TRUE,
  silent = NULL
)

Arguments

obj

The source NIF object.

analyte

The analyte. If none specified and multiple analytes are in the dataset, defaults to the first analyte.

parent

The parent compound to derive the administration information from. By default, equal to the analyte.

keep

A vector of fields to retain on the subject level in the output.

group

The grouping variable as string.

nominal_time

A boolean to indicate whether nominal time rather than actual time should be used for NCA.

average_duplicates

Boolean to indicate whether duplicate entries should be averaged.

silent

Suppress messages, defaults to nif_option setting, if NULL.

Value

A data frame.

Examples

nca(examplinib_fe_nif)
#> NCA: No analyte specified. Selected RS2023 as the most likely.
#> Warning: Negative concentrations found
#> Warning: Negative concentrations found
#> Warning: NaNs produced
#> Warning: Negative concentrations found
#> Warning: Negative concentrations found
#> Warning: Negative concentrations found
#> Warning: NaNs produced
#> Warning: Negative concentrations found
#> Warning: Negative concentrations found
#> Warning: Negative concentrations found
#> Warning: NaNs produced
#> Warning: Negative concentrations found
#> Warning: Negative concentrations found
#> Warning: Negative concentrations found
#> Warning: NaNs produced
#> Warning: Negative concentrations found
#> Warning: Negative concentrations found
#> 
#>    ID start end PPTESTCD   PPORRES exclude DOSE
#> 1   1     0 312  auclast       NaN    <NA>  500
#> 2   1     0 312     cmax  6325.101    <NA>  500
#> 3   1     0 312     tmax     1.000    <NA>  500
#> 4   2     0 312  auclast 18252.638    <NA>  500
#> 5   2     0 312     cmax  2789.380    <NA>  500
#> 6   2     0 312     tmax     2.000    <NA>  500
#> 7   3     0 312  auclast 21508.110    <NA>  500
#> 8   3     0 312     cmax  6439.872    <NA>  500
#> 9   3     0 312     tmax     1.000    <NA>  500
#> 10  4     0 312  auclast 24912.778    <NA>  500
#> 11  4     0 312     cmax  6043.145    <NA>  500
#> 12  4     0 312     tmax     1.500    <NA>  500
#> 13  5     0 312  auclast 32624.194    <NA>  500
#> 14  5     0 312     cmax  5283.736    <NA>  500
#> 15  5     0 312     tmax     2.000    <NA>  500
#> 16  6     0 312  auclast 26174.681    <NA>  500
#> 17  6     0 312     cmax  4106.337    <NA>  500
#> 18  6     0 312     tmax     2.000    <NA>  500
#> 19  7     0 312  auclast       NaN    <NA>  500
#> 20  7     0 312     cmax  3525.703    <NA>  500
#> 21  7     0 312     tmax     3.000    <NA>  500
#> 22  8     0 312  auclast       NaN    <NA>  500
#> 23  8     0 312     cmax  6994.537    <NA>  500
#> 24  8     0 312     tmax     1.500    <NA>  500
#> 25  9     0 312  auclast 40878.720    <NA>  500
#> 26  9     0 312     cmax  5496.735    <NA>  500
#> 27  9     0 312     tmax     3.000    <NA>  500
#> 28 10     0 312  auclast 26751.872    <NA>  500
#> 29 10     0 312     cmax  3842.711    <NA>  500
#> 30 10     0 312     tmax     2.000    <NA>  500
#> 31 11     0 312  auclast 21929.126    <NA>  500
#> 32 11     0 312     cmax  3166.345    <NA>  500
#> 33 11     0 312     tmax     2.000    <NA>  500
#> 34 12     0 312  auclast 23243.084    <NA>  500
#> 35 12     0 312     cmax  5426.283    <NA>  500
#> 36 12     0 312     tmax     1.500    <NA>  500
#> 37 13     0 312  auclast       NaN    <NA>  500
#> 38 13     0 312     cmax  4815.076    <NA>  500
#> 39 13     0 312     tmax     2.000    <NA>  500
#> 40 14     0 312  auclast 13736.851    <NA>  500
#> 41 14     0 312     cmax  4489.737    <NA>  500
#> 42 14     0 312     tmax     1.000    <NA>  500
#> 43 15     0 312  auclast 48328.416    <NA>  500
#> 44 15     0 312     cmax  6801.036    <NA>  500
#> 45 15     0 312     tmax     3.000    <NA>  500
#> 46 16     0 312  auclast 19915.700    <NA>  500
#> 47 16     0 312     cmax  5547.706    <NA>  500
#> 48 16     0 312     tmax     1.500    <NA>  500
#> 49 17     0 312  auclast 20075.151    <NA>  500
#> 50 17     0 312     cmax  5447.778    <NA>  500
#> 51 17     0 312     tmax     1.500    <NA>  500
#> 52 18     0 312  auclast 26635.716    <NA>  500
#> 53 18     0 312     cmax  6407.331    <NA>  500
#> 54 18     0 312     tmax     1.500    <NA>  500
#> 55 19     0 312  auclast 25325.634    <NA>  500
#> 56 19     0 312     cmax  3516.646    <NA>  500
#> 57 19     0 312     tmax     3.000    <NA>  500
#> 58 20     0 312  auclast 13780.457    <NA>  500
#> 59 20     0 312     cmax  4126.813    <NA>  500
#> 60 20     0 312     tmax     1.000    <NA>  500
nca(examplinib_fe_nif, group = c("FASTED", "SEX"), analyte = "RS2023")
#> NCA: Group byFASTED+SEX
#> Warning: Negative concentrations found
#> Warning: Negative concentrations found
#> Warning: Negative concentrations found
#> Warning: Negative concentrations found
#> Warning: Negative concentrations found
#> Warning: Negative concentrations found
#> Warning: Negative concentrations found
#> Warning: Negative concentrations found
#> Warning: NaNs produced
#> Warning: Negative concentrations found
#> Warning: Negative concentrations found
#> Warning: Negative concentrations found
#> Warning: Negative concentrations found
#> Warning: Negative concentrations found
#> Warning: Negative concentrations found
#> Warning: Negative concentrations found
#> Warning: Negative concentrations found
#> Warning: NaNs produced
#> Warning: Negative concentrations found
#> Warning: Negative concentrations found
#> Warning: Negative concentrations found
#> Warning: Negative concentrations found
#> Warning: Negative concentrations found
#> Warning: Negative concentrations found
#> Warning: Negative concentrations found
#> Warning: Negative concentrations found
#> Warning: NaNs produced
#> Warning: Negative concentrations found
#> Warning: Negative concentrations found
#> Warning: Negative concentrations found
#> Warning: Negative concentrations found
#> Warning: Negative concentrations found
#> Warning: Negative concentrations found
#> Warning: Negative concentrations found
#> Warning: Negative concentrations found
#> Warning: NaNs produced
#> Warning: Negative concentrations found
#> 
#>     FASTED SEX ID start end            PPTESTCD      PPORRES exclude DOSE
#> 1        1   1  1     0  24             auclast 2.504642e+04    <NA>  500
#> 2        1   1  1     0 Inf                cmax 6.325101e+03    <NA>  500
#> 3        1   1  1     0 Inf                tmax 1.000000e+00    <NA>  500
#> 4        1   1  1     0 Inf               tlast 1.680000e+02    <NA>  500
#> 5        1   1  1     0 Inf           clast.obs 9.704193e-05    <NA>  500
#> 6        1   1  1     0 Inf            lambda.z 8.895551e-02    <NA>  500
#> 7        1   1  1     0 Inf           r.squared 9.999811e-01    <NA>  500
#> 8        1   1  1     0 Inf       adj.r.squared 9.999764e-01    <NA>  500
#> 9        1   1  1     0 Inf lambda.z.time.first 2.400000e+01    <NA>  500
#> 10       1   1  1     0 Inf   lambda.z.n.points 6.000000e+00    <NA>  500
#> 11       1   1  1     0 Inf          clast.pred 9.649364e-05    <NA>  500
#> 12       1   1  1     0 Inf           half.life 7.792066e+00    <NA>  500
#> 13       1   1  1     0 Inf          span.ratio 1.848034e+01    <NA>  500
#> 14       1   1  1     0 Inf          aucinf.obs 2.544210e+04    <NA>  500
#> 15       0   1  1   312 336             auclast 3.431709e+04    <NA>  500
#> 16       0   1  1   312 Inf                cmax 4.956902e+03    <NA>  500
#> 17       0   1  1   312 Inf                tmax 3.000000e+00    <NA>  500
#> 18       0   1  1   312 Inf               tlast 1.680000e+02    <NA>  500
#> 19       0   1  1   312 Inf           clast.obs 1.845688e-04    <NA>  500
#> 20       0   1  1   312 Inf            lambda.z 8.884753e-02    <NA>  500
#> 21       0   1  1   312 Inf           r.squared 9.999968e-01    <NA>  500
#> 22       0   1  1   312 Inf       adj.r.squared 9.999958e-01    <NA>  500
#> 23       0   1  1   312 Inf lambda.z.time.first 4.800000e+01    <NA>  500
#> 24       0   1  1   312 Inf   lambda.z.n.points 5.000000e+00    <NA>  500
#> 25       0   1  1   312 Inf          clast.pred 1.853255e-04    <NA>  500
#> 26       0   1  1   312 Inf           half.life 7.801536e+00    <NA>  500
#> 27       0   1  1   312 Inf          span.ratio 1.538159e+01    <NA>  500
#> 28       0   1  1   312 Inf          aucinf.obs 3.521725e+04    <NA>  500
#> 29       0   1  2     0  24             auclast 1.787013e+04    <NA>  500
#> 30       0   1  2     0 Inf                cmax 2.789380e+03    <NA>  500
#> 31       0   1  2     0 Inf                tmax 2.000000e+00    <NA>  500
#> 32       0   1  2     0 Inf               tlast 1.680000e+02    <NA>  500
#> 33       0   1  2     0 Inf           clast.obs 4.580125e-05    <NA>  500
#> 34       0   1  2     0 Inf            lambda.z 9.187966e-02    <NA>  500
#> 35       0   1  2     0 Inf           r.squared 9.999718e-01    <NA>  500
#> 36       0   1  2     0 Inf       adj.r.squared 9.999624e-01    <NA>  500
#> 37       0   1  2     0 Inf lambda.z.time.first 4.800000e+01    <NA>  500
#> 38       0   1  2     0 Inf   lambda.z.n.points 5.000000e+00    <NA>  500
#> 39       0   1  2     0 Inf          clast.pred 4.548237e-05    <NA>  500
#> 40       0   1  2     0 Inf           half.life 7.544077e+00    <NA>  500
#> 41       0   1  2     0 Inf          span.ratio 1.590652e+01    <NA>  500
#> 42       0   1  2     0 Inf          aucinf.obs 1.825264e+04    <NA>  500
#> 43       1   1  2   312 336             auclast 1.178450e+04    <NA>  500
#> 44       1   1  2   312 Inf                cmax 3.431745e+03    <NA>  500
#> 45       1   1  2   312 Inf                tmax 1.000000e+00    <NA>  500
#> 46       1   1  2   312 Inf               tlast 1.680000e+02    <NA>  500
#> 47       1   1  2   312 Inf           clast.obs 2.193043e-05    <NA>  500
#> 48       1   1  2   312 Inf            lambda.z 9.165476e-02    <NA>  500
#> 49       1   1  2   312 Inf           r.squared 9.999814e-01    <NA>  500
#> 50       1   1  2   312 Inf       adj.r.squared 9.999768e-01    <NA>  500
#> 51       1   1  2   312 Inf lambda.z.time.first 2.400000e+01    <NA>  500
#> 52       1   1  2   312 Inf   lambda.z.n.points 6.000000e+00    <NA>  500
#> 53       1   1  2   312 Inf          clast.pred 2.148559e-05    <NA>  500
#> 54       1   1  2   312 Inf           half.life 7.562588e+00    <NA>  500
#> 55       1   1  2   312 Inf          span.ratio 1.904110e+01    <NA>  500
#> 56       1   1  2   312 Inf          aucinf.obs 1.191081e+04    <NA>  500
#> 57       1   1  3     0  24             auclast 2.127273e+04    <NA>  500
#> 58       1   1  3     0 Inf                cmax 6.439872e+03    <NA>  500
#> 59       1   1  3     0 Inf                tmax 1.000000e+00    <NA>  500
#> 60       1   1  3     0 Inf               tlast 1.680000e+02    <NA>  500
#> 61       1   1  3     0 Inf           clast.obs 7.390936e-06    <NA>  500
#> 62       1   1  3     0 Inf            lambda.z 1.047673e-01    <NA>  500
#> 63       1   1  3     0 Inf           r.squared 9.999660e-01    <NA>  500
#> 64       1   1  3     0 Inf       adj.r.squared 9.999592e-01    <NA>  500
#> 65       1   1  3     0 Inf lambda.z.time.first 1.200000e+01    <NA>  500
#> 66       1   1  3     0 Inf   lambda.z.n.points 7.000000e+00    <NA>  500
#> 67       1   1  3     0 Inf          clast.pred 7.106165e-06    <NA>  500
#> 68       1   1  3     0 Inf           half.life 6.616064e+00    <NA>  500
#> 69       1   1  3     0 Inf          span.ratio 2.357897e+01    <NA>  500
#> 70       1   1  3     0 Inf          aucinf.obs 2.150811e+04    <NA>  500
#> 71       0   1  3   312 336             auclast 3.058559e+04    <NA>  500
#> 72       0   1  3   312 Inf                cmax 4.767907e+03    <NA>  500
#> 73       0   1  3   312 Inf                tmax 2.000000e+00    <NA>  500
#> 74       0   1  3   312 Inf               tlast 1.680000e+02    <NA>  500
#> 75       0   1  3   312 Inf           clast.obs 1.462743e-05    <NA>  500
#> 76       0   1  3   312 Inf            lambda.z 1.045455e-01    <NA>  500
#> 77       0   1  3   312 Inf           r.squared 9.999830e-01    <NA>  500
#> 78       0   1  3   312 Inf       adj.r.squared 9.999773e-01    <NA>  500
#> 79       0   1  3   312 Inf lambda.z.time.first 4.800000e+01    <NA>  500
#> 80       0   1  3   312 Inf   lambda.z.n.points 5.000000e+00    <NA>  500
#> 81       0   1  3   312 Inf          clast.pred 1.458709e-05    <NA>  500
#> 82       0   1  3   312 Inf           half.life 6.630102e+00    <NA>  500
#> 83       0   1  3   312 Inf          span.ratio 1.809927e+01    <NA>  500
#> 84       0   1  3   312 Inf          aucinf.obs 3.116406e+04    <NA>  500
#> 85       1   1  4     0  24             auclast 2.443897e+04    <NA>  500
#> 86       1   1  4     0 Inf                cmax 6.043145e+03    <NA>  500
#> 87       1   1  4     0 Inf                tmax 1.500000e+00    <NA>  500
#> 88       1   1  4     0 Inf               tlast 1.680000e+02    <NA>  500
#> 89       1   1  4     0 Inf           clast.obs 1.984748e-04    <NA>  500
#> 90       1   1  4     0 Inf            lambda.z 8.484051e-02    <NA>  500
#> 91       1   1  4     0 Inf           r.squared 9.999722e-01    <NA>  500
#> 92       1   1  4     0 Inf       adj.r.squared 9.999652e-01    <NA>  500
#> 93       1   1  4     0 Inf lambda.z.time.first 2.400000e+01    <NA>  500
#> 94       1   1  4     0 Inf   lambda.z.n.points 6.000000e+00    <NA>  500
#> 95       1   1  4     0 Inf          clast.pred 1.988844e-04    <NA>  500
#> 96       1   1  4     0 Inf           half.life 8.170002e+00    <NA>  500
#> 97       1   1  4     0 Inf          span.ratio 1.762545e+01    <NA>  500
#> 98       1   1  4     0 Inf          aucinf.obs 2.491278e+04    <NA>  500
#> 99       0   1  4   312 336             auclast 3.817864e+04    <NA>  500
#> 100      0   1  4   312 Inf                cmax 5.333942e+03    <NA>  500
#> 101      0   1  4   312 Inf                tmax 2.000000e+00    <NA>  500
#> 102      0   1  4   312 Inf               tlast 1.680000e+02    <NA>  500
#> 103      0   1  4   312 Inf           clast.obs 3.870134e-04    <NA>  500
#> 104      0   1  4   312 Inf            lambda.z 8.522916e-02    <NA>  500
#> 105      0   1  4   312 Inf           r.squared 9.999328e-01    <NA>  500
#> 106      0   1  4   312 Inf       adj.r.squared 9.999104e-01    <NA>  500
#> 107      0   1  4   312 Inf lambda.z.time.first 4.800000e+01    <NA>  500
#> 108      0   1  4   312 Inf   lambda.z.n.points 5.000000e+00    <NA>  500
#> 109      0   1  4   312 Inf          clast.pred 4.005540e-04    <NA>  500
#> 110      0   1  4   312 Inf           half.life 8.132747e+00    <NA>  500
#> 111      0   1  4   312 Inf          span.ratio 1.475516e+01    <NA>  500
#> 112      0   1  4   312 Inf          aucinf.obs 3.934480e+04    <NA>  500
#> 113      0   0  5     0  24             auclast 3.202317e+04    <NA>  500
#> 114      0   0  5     0 Inf                cmax 5.283736e+03    <NA>  500
#> 115      0   0  5     0 Inf                tmax 2.000000e+00    <NA>  500
#> 116      0   0  5     0 Inf               tlast 1.680000e+02    <NA>  500
#> 117      0   0  5     0 Inf           clast.obs 3.525085e-05    <NA>  500
#> 118      0   0  5     0 Inf            lambda.z 9.840913e-02    <NA>  500
#> 119      0   0  5     0 Inf           r.squared 9.999789e-01    <NA>  500
#> 120      0   0  5     0 Inf       adj.r.squared 9.999718e-01    <NA>  500
#> 121      0   0  5     0 Inf lambda.z.time.first 4.800000e+01    <NA>  500
#> 122      0   0  5     0 Inf   lambda.z.n.points 5.000000e+00    <NA>  500
#> 123      0   0  5     0 Inf          clast.pred 3.514853e-05    <NA>  500
#> 124      0   0  5     0 Inf           half.life 7.043525e+00    <NA>  500
#> 125      0   0  5     0 Inf          span.ratio 1.703692e+01    <NA>  500
#> 126      0   0  5     0 Inf          aucinf.obs 3.262419e+04    <NA>  500
#> 127      1   0  5   312 336             auclast 2.316675e+04    <NA>  500
#> 128      1   0  5   312 Inf                cmax 7.048011e+03    <NA>  500
#> 129      1   0  5   312 Inf                tmax 1.000000e+00    <NA>  500
#> 130      1   0  5   312 Inf               tlast 1.680000e+02    <NA>  500
#> 131      1   0  5   312 Inf           clast.obs 1.856992e-05    <NA>  500
#> 132      1   0  5   312 Inf            lambda.z 9.916635e-02    <NA>  500
#> 133      1   0  5   312 Inf           r.squared 9.999721e-01    <NA>  500
#> 134      1   0  5   312 Inf       adj.r.squared 9.999665e-01    <NA>  500
#> 135      1   0  5   312 Inf lambda.z.time.first 1.200000e+01    <NA>  500
#> 136      1   0  5   312 Inf   lambda.z.n.points 7.000000e+00    <NA>  500
#> 137      1   0  5   312 Inf          clast.pred 1.843892e-05    <NA>  500
#> 138      1   0  5   312 Inf           half.life 6.989742e+00    <NA>  500
#> 139      1   0  5   312 Inf          span.ratio 2.231842e+01    <NA>  500
#> 140      1   0  5   312 Inf          aucinf.obs 2.345301e+04    <NA>  500
#> 141      0   1  6     0  24             auclast 2.563207e+04    <NA>  500
#> 142      0   1  6     0 Inf                cmax 4.106337e+03    <NA>  500
#> 143      0   1  6     0 Inf                tmax 2.000000e+00    <NA>  500
#> 144      0   1  6     0 Inf               tlast 1.680000e+02    <NA>  500
#> 145      0   1  6     0 Inf           clast.obs 2.177254e-04    <NA>  500
#> 146      0   1  6     0 Inf            lambda.z 8.351055e-02    <NA>  500
#> 147      0   1  6     0 Inf           r.squared 9.999362e-01    <NA>  500
#> 148      0   1  6     0 Inf       adj.r.squared 9.999149e-01    <NA>  500
#> 149      0   1  6     0 Inf lambda.z.time.first 4.800000e+01    <NA>  500
#> 150      0   1  6     0 Inf   lambda.z.n.points 5.000000e+00    <NA>  500
#> 151      0   1  6     0 Inf          clast.pred 2.177732e-04    <NA>  500
#> 152      0   1  6     0 Inf           half.life 8.300115e+00    <NA>  500
#> 153      0   1  6     0 Inf          span.ratio 1.445763e+01    <NA>  500
#> 154      0   1  6     0 Inf          aucinf.obs 2.617468e+04    <NA>  500
#> 155      1   1  6   312 336             auclast 1.899695e+04    <NA>  500
#> 156      1   1  6   312 Inf                cmax 5.739598e+03    <NA>  500
#> 157      1   1  6   312 Inf                tmax 1.000000e+00    <NA>  500
#> 158      1   1  6   312 Inf               tlast 1.680000e+02    <NA>  500
#> 159      1   1  6   312 Inf           clast.obs 1.165818e-04    <NA>  500
#> 160      1   1  6   312 Inf            lambda.z 8.317751e-02    <NA>  500
#> 161      1   1  6   312 Inf           r.squared 9.999067e-01    <NA>  500
#> 162      1   1  6   312 Inf       adj.r.squared 9.998833e-01    <NA>  500
#> 163      1   1  6   312 Inf lambda.z.time.first 2.400000e+01    <NA>  500
#> 164      1   1  6   312 Inf   lambda.z.n.points 6.000000e+00    <NA>  500
#> 165      1   1  6   312 Inf          clast.pred 1.225531e-04    <NA>  500
#> 166      1   1  6   312 Inf           half.life 8.333349e+00    <NA>  500
#> 167      1   1  6   312 Inf          span.ratio 1.727997e+01    <NA>  500
#> 168      1   1  6   312 Inf          aucinf.obs 1.922765e+04    <NA>  500
#> 169      0   1  7     0  24             auclast 2.479636e+04    <NA>  500
#> 170      0   1  7     0 Inf                cmax 3.525703e+03    <NA>  500
#> 171      0   1  7     0 Inf                tmax 3.000000e+00    <NA>  500
#> 172      0   1  7     0 Inf               tlast 1.680000e+02    <NA>  500
#> 173      0   1  7     0 Inf           clast.obs 2.398994e-05    <NA>  500
#> 174      0   1  7     0 Inf            lambda.z 9.960954e-02    <NA>  500
#> 175      0   1  7     0 Inf           r.squared 9.999575e-01    <NA>  500
#> 176      0   1  7     0 Inf       adj.r.squared 9.999433e-01    <NA>  500
#> 177      0   1  7     0 Inf lambda.z.time.first 4.800000e+01    <NA>  500
#> 178      0   1  7     0 Inf   lambda.z.n.points 5.000000e+00    <NA>  500
#> 179      0   1  7     0 Inf          clast.pred 2.430465e-05    <NA>  500
#> 180      0   1  7     0 Inf           half.life 6.958642e+00    <NA>  500
#> 181      0   1  7     0 Inf          span.ratio 1.724474e+01    <NA>  500
#> 182      0   1  7     0 Inf          aucinf.obs 2.536877e+04    <NA>  500
#> 183      1   1  7   312 336             auclast 1.878799e+04    <NA>  500
#> 184      1   1  7   312 Inf                cmax 5.463950e+03    <NA>  500
#> 185      1   1  7   312 Inf                tmax 1.000000e+00    <NA>  500
#> 186      1   1  7   312 Inf               tlast 1.680000e+02    <NA>  500
#> 187      1   1  7   312 Inf           clast.obs 1.318929e-05    <NA>  500
#> 188      1   1  7   312 Inf            lambda.z 9.906323e-02    <NA>  500
#> 189      1   1  7   312 Inf           r.squared 9.999512e-01    <NA>  500
#> 190      1   1  7   312 Inf       adj.r.squared 9.999390e-01    <NA>  500
#> 191      1   1  7   312 Inf lambda.z.time.first 2.400000e+01    <NA>  500
#> 192      1   1  7   312 Inf   lambda.z.n.points 6.000000e+00    <NA>  500
#> 193      1   1  7   312 Inf          clast.pred 1.290949e-05    <NA>  500
#> 194      1   1  7   312 Inf           half.life 6.997018e+00    <NA>  500
#> 195      1   1  7   312 Inf          span.ratio 2.058020e+01    <NA>  500
#> 196      1   1  7   312 Inf          aucinf.obs 1.899722e+04    <NA>  500
#> 197      1   0  8     0  24             auclast 2.721779e+04    <NA>  500
#> 198      1   0  8     0 Inf                cmax 6.994537e+03    <NA>  500
#> 199      1   0  8     0 Inf                tmax 1.500000e+00    <NA>  500
#> 200      1   0  8     0 Inf               tlast 1.680000e+02    <NA>  500
#> 201      1   0  8     0 Inf           clast.obs 7.224614e-05    <NA>  500
#> 202      1   0  8     0 Inf            lambda.z 9.219047e-02    <NA>  500
#> 203      1   0  8     0 Inf           r.squared 9.999442e-01    <NA>  500
#> 204      1   0  8     0 Inf       adj.r.squared 9.999330e-01    <NA>  500
#> 205      1   0  8     0 Inf lambda.z.time.first 1.200000e+01    <NA>  500
#> 206      1   0  8     0 Inf   lambda.z.n.points 7.000000e+00    <NA>  500
#> 207      1   0  8     0 Inf          clast.pred 7.169306e-05    <NA>  500
#> 208      1   0  8     0 Inf           half.life 7.518643e+00    <NA>  500
#> 209      1   0  8     0 Inf          span.ratio 2.074843e+01    <NA>  500
#> 210      1   0  8     0 Inf          aucinf.obs 2.765162e+04    <NA>  500
#> 211      0   0  8   312 336             auclast 3.788023e+04    <NA>  500
#> 212      0   0  8   312 Inf                cmax 5.483093e+03    <NA>  500
#> 213      0   0  8   312 Inf                tmax 2.000000e+00    <NA>  500
#> 214      0   0  8   312 Inf               tlast 1.680000e+02    <NA>  500
#> 215      0   0  8   312 Inf           clast.obs 1.471476e-04    <NA>  500
#> 216      0   0  8   312 Inf            lambda.z 9.125122e-02    <NA>  500
#> 217      0   0  8   312 Inf           r.squared 9.999876e-01    <NA>  500
#> 218      0   0  8   312 Inf       adj.r.squared 9.999835e-01    <NA>  500
#> 219      0   0  8   312 Inf lambda.z.time.first 4.800000e+01    <NA>  500
#> 220      0   0  8   312 Inf   lambda.z.n.points 5.000000e+00    <NA>  500
#> 221      0   0  8   312 Inf          clast.pred 1.451554e-04    <NA>  500
#> 222      0   0  8   312 Inf           half.life 7.596032e+00    <NA>  500
#> 223      0   0  8   312 Inf          span.ratio 1.579772e+01    <NA>  500
#> 224      0   0  8   312 Inf          aucinf.obs 3.886029e+04    <NA>  500
#> 225      0   0  9     0  24             auclast 3.965673e+04    <NA>  500
#> 226      0   0  9     0 Inf                cmax 5.496735e+03    <NA>  500
#> 227      0   0  9     0 Inf                tmax 3.000000e+00    <NA>  500
#> 228      0   0  9     0 Inf               tlast 1.680000e+02    <NA>  500
#> 229      0   0  9     0 Inf           clast.obs 2.767436e-04    <NA>  500
#> 230      0   0  9     0 Inf            lambda.z 8.765911e-02    <NA>  500
#> 231      0   0  9     0 Inf           r.squared 9.999889e-01    <NA>  500
#> 232      0   0  9     0 Inf       adj.r.squared 9.999852e-01    <NA>  500
#> 233      0   0  9     0 Inf lambda.z.time.first 4.800000e+01    <NA>  500
#> 234      0   0  9     0 Inf   lambda.z.n.points 5.000000e+00    <NA>  500
#> 235      0   0  9     0 Inf          clast.pred 2.815239e-04    <NA>  500
#> 236      0   0  9     0 Inf           half.life 7.907304e+00    <NA>  500
#> 237      0   0  9     0 Inf          span.ratio 1.517584e+01    <NA>  500
#> 238      0   0  9     0 Inf          aucinf.obs 4.087872e+04    <NA>  500
#> 239      1   0  9   312 336             auclast 2.903697e+04    <NA>  500
#> 240      1   0  9   312 Inf                cmax 7.358267e+03    <NA>  500
#> 241      1   0  9   312 Inf                tmax 1.500000e+00    <NA>  500
#> 242      1   0  9   312 Inf               tlast 1.680000e+02    <NA>  500
#> 243      1   0  9   312 Inf           clast.obs 1.519074e-04    <NA>  500
#> 244      1   0  9   312 Inf            lambda.z 8.781736e-02    <NA>  500
#> 245      1   0  9   312 Inf           r.squared 9.999437e-01    <NA>  500
#> 246      1   0  9   312 Inf       adj.r.squared 9.999297e-01    <NA>  500
#> 247      1   0  9   312 Inf lambda.z.time.first 2.400000e+01    <NA>  500
#> 248      1   0  9   312 Inf   lambda.z.n.points 6.000000e+00    <NA>  500
#> 249      1   0  9   312 Inf          clast.pred 1.437517e-04    <NA>  500
#> 250      1   0  9   312 Inf           half.life 7.893054e+00    <NA>  500
#> 251      1   0  9   312 Inf          span.ratio 1.824389e+01    <NA>  500
#> 252      1   0  9   312 Inf          aucinf.obs 2.955187e+04    <NA>  500
#> 253      0   0 10     0  24             auclast 2.608545e+04    <NA>  500
#> 254      0   0 10     0 Inf                cmax 3.842711e+03    <NA>  500
#> 255      0   0 10     0 Inf                tmax 2.000000e+00    <NA>  500
#> 256      0   0 10     0 Inf               tlast 1.680000e+02    <NA>  500
#> 257      0   0 10     0 Inf           clast.obs 2.539811e-04    <NA>  500
#> 258      0   0 10     0 Inf            lambda.z 8.367580e-02    <NA>  500
#> 259      0   0 10     0 Inf           r.squared 9.999242e-01    <NA>  500
#> 260      0   0 10     0 Inf       adj.r.squared 9.998989e-01    <NA>  500
#> 261      0   0 10     0 Inf lambda.z.time.first 4.800000e+01    <NA>  500
#> 262      0   0 10     0 Inf   lambda.z.n.points 5.000000e+00    <NA>  500
#> 263      0   0 10     0 Inf          clast.pred 2.446392e-04    <NA>  500
#> 264      0   0 10     0 Inf           half.life 8.283723e+00    <NA>  500
#> 265      0   0 10     0 Inf          span.ratio 1.448624e+01    <NA>  500
#> 266      0   0 10     0 Inf          aucinf.obs 2.675187e+04    <NA>  500
#> 267      1   0 10   312 336             auclast 1.772037e+04    <NA>  500
#> 268      1   0 10   312 Inf                cmax 4.871447e+03    <NA>  500
#> 269      1   0 10   312 Inf                tmax 1.000000e+00    <NA>  500
#> 270      1   0 10   312 Inf               tlast 1.680000e+02    <NA>  500
#> 271      1   0 10   312 Inf           clast.obs 1.237101e-04    <NA>  500
#> 272      1   0 10   312 Inf            lambda.z 8.358936e-02    <NA>  500
#> 273      1   0 10   312 Inf           r.squared 9.999874e-01    <NA>  500
#> 274      1   0 10   312 Inf       adj.r.squared 9.999842e-01    <NA>  500
#> 275      1   0 10   312 Inf lambda.z.time.first 2.400000e+01    <NA>  500
#> 276      1   0 10   312 Inf   lambda.z.n.points 6.000000e+00    <NA>  500
#> 277      1   0 10   312 Inf          clast.pred 1.237650e-04    <NA>  500
#> 278      1   0 10   312 Inf           half.life 8.292290e+00    <NA>  500
#> 279      1   0 10   312 Inf          span.ratio 1.736553e+01    <NA>  500
#> 280      1   0 10   312 Inf          aucinf.obs 1.797195e+04    <NA>  500
#> 281      0   0 11     0  24             auclast 2.142685e+04    <NA>  500
#> 282      0   0 11     0 Inf                cmax 3.166345e+03    <NA>  500
#> 283      0   0 11     0 Inf                tmax 2.000000e+00    <NA>  500
#> 284      0   0 11     0 Inf               tlast 1.680000e+02    <NA>  500
#> 285      0   0 11     0 Inf           clast.obs 3.574064e-05    <NA>  500
#> 286      0   0 11     0 Inf            lambda.z 9.556086e-02    <NA>  500
#> 287      0   0 11     0 Inf           r.squared 9.999791e-01    <NA>  500
#> 288      0   0 11     0 Inf       adj.r.squared 9.999722e-01    <NA>  500
#> 289      0   0 11     0 Inf lambda.z.time.first 4.800000e+01    <NA>  500
#> 290      0   0 11     0 Inf   lambda.z.n.points 5.000000e+00    <NA>  500
#> 291      0   0 11     0 Inf          clast.pred 3.653020e-05    <NA>  500
#> 292      0   0 11     0 Inf           half.life 7.253464e+00    <NA>  500
#> 293      0   0 11     0 Inf          span.ratio 1.654382e+01    <NA>  500
#> 294      0   0 11     0 Inf          aucinf.obs 2.192913e+04    <NA>  500
#> 295      1   0 11   312 336             auclast 1.520481e+04    <NA>  500
#> 296      1   0 11   312 Inf                cmax 4.223442e+03    <NA>  500
#> 297      1   0 11   312 Inf                tmax 1.000000e+00    <NA>  500
#> 298      1   0 11   312 Inf               tlast 1.680000e+02    <NA>  500
#> 299      1   0 11   312 Inf           clast.obs 1.658599e-05    <NA>  500
#> 300      1   0 11   312 Inf            lambda.z 9.590341e-02    <NA>  500
#> 301      1   0 11   312 Inf           r.squared 9.999848e-01    <NA>  500
#> 302      1   0 11   312 Inf       adj.r.squared 9.999810e-01    <NA>  500
#> 303      1   0 11   312 Inf lambda.z.time.first 2.400000e+01    <NA>  500
#> 304      1   0 11   312 Inf   lambda.z.n.points 6.000000e+00    <NA>  500
#> 305      1   0 11   312 Inf          clast.pred 1.665633e-05    <NA>  500
#> 306      1   0 11   312 Inf           half.life 7.227555e+00    <NA>  500
#> 307      1   0 11   312 Inf          span.ratio 1.992375e+01    <NA>  500
#> 308      1   0 11   312 Inf          aucinf.obs 1.537818e+04    <NA>  500
#> 309      1   0 12     0  24             auclast 2.288086e+04    <NA>  500
#> 310      1   0 12     0 Inf                cmax 5.426283e+03    <NA>  500
#> 311      1   0 12     0 Inf                tmax 1.500000e+00    <NA>  500
#> 312      1   0 12     0 Inf               tlast 1.680000e+02    <NA>  500
#> 313      1   0 12     0 Inf           clast.obs 5.739693e-05    <NA>  500
#> 314      1   0 12     0 Inf            lambda.z 9.219572e-02    <NA>  500
#> 315      1   0 12     0 Inf           r.squared 9.999707e-01    <NA>  500
#> 316      1   0 12     0 Inf       adj.r.squared 9.999633e-01    <NA>  500
#> 317      1   0 12     0 Inf lambda.z.time.first 2.400000e+01    <NA>  500
#> 318      1   0 12     0 Inf   lambda.z.n.points 6.000000e+00    <NA>  500
#> 319      1   0 12     0 Inf          clast.pred 5.638430e-05    <NA>  500
#> 320      1   0 12     0 Inf           half.life 7.518214e+00    <NA>  500
#> 321      1   0 12     0 Inf          span.ratio 1.915348e+01    <NA>  500
#> 322      1   0 12     0 Inf          aucinf.obs 2.324308e+04    <NA>  500
#> 323      0   0 12   312 336             auclast 3.274660e+04    <NA>  500
#> 324      0   0 12   312 Inf                cmax 4.500265e+03    <NA>  500
#> 325      0   0 12   312 Inf                tmax 2.000000e+00    <NA>  500
#> 326      0   0 12   312 Inf               tlast 1.680000e+02    <NA>  500
#> 327      0   0 12   312 Inf           clast.obs 1.192893e-04    <NA>  500
#> 328      0   0 12   312 Inf            lambda.z 9.264301e-02    <NA>  500
#> 329      0   0 12   312 Inf           r.squared 9.999919e-01    <NA>  500
#> 330      0   0 12   312 Inf       adj.r.squared 9.999892e-01    <NA>  500
#> 331      0   0 12   312 Inf lambda.z.time.first 4.800000e+01    <NA>  500
#> 332      0   0 12   312 Inf   lambda.z.n.points 5.000000e+00    <NA>  500
#> 333      0   0 12   312 Inf          clast.pred 1.178746e-04    <NA>  500
#> 334      0   0 12   312 Inf           half.life 7.481916e+00    <NA>  500
#> 335      0   0 12   312 Inf          span.ratio 1.603867e+01    <NA>  500
#> 336      0   0 12   312 Inf          aucinf.obs 3.377363e+04    <NA>  500
#> 337      0   0 13     0  24             auclast 2.661068e+04    <NA>  500
#> 338      0   0 13     0 Inf                cmax 4.815076e+03    <NA>  500
#> 339      0   0 13     0 Inf                tmax 2.000000e+00    <NA>  500
#> 340      0   0 13     0 Inf               tlast 1.680000e+02    <NA>  500
#> 341      0   0 13     0 Inf           clast.obs 9.344742e-05    <NA>  500
#> 342      0   0 13     0 Inf            lambda.z 8.991307e-02    <NA>  500
#> 343      0   0 13     0 Inf           r.squared 9.999727e-01    <NA>  500
#> 344      0   0 13     0 Inf       adj.r.squared 9.999636e-01    <NA>  500
#> 345      0   0 13     0 Inf lambda.z.time.first 4.800000e+01    <NA>  500
#> 346      0   0 13     0 Inf   lambda.z.n.points 5.000000e+00    <NA>  500
#> 347      0   0 13     0 Inf          clast.pred 9.330874e-05    <NA>  500
#> 348      0   0 13     0 Inf           half.life 7.709082e+00    <NA>  500
#> 349      0   0 13     0 Inf          span.ratio 1.556606e+01    <NA>  500
#> 350      0   0 13     0 Inf          aucinf.obs 2.709179e+04    <NA>  500
#> 351      1   0 13   312 336             auclast 1.839950e+04    <NA>  500
#> 352      1   0 13   312 Inf                cmax 5.777191e+03    <NA>  500
#> 353      1   0 13   312 Inf                tmax 1.000000e+00    <NA>  500
#> 354      1   0 13   312 Inf               tlast 1.680000e+02    <NA>  500
#> 355      1   0 13   312 Inf           clast.obs 5.534060e-05    <NA>  500
#> 356      1   0 13   312 Inf            lambda.z 9.011662e-02    <NA>  500
#> 357      1   0 13   312 Inf           r.squared 9.999682e-01    <NA>  500
#> 358      1   0 13   312 Inf       adj.r.squared 9.999618e-01    <NA>  500
#> 359      1   0 13   312 Inf lambda.z.time.first 1.200000e+01    <NA>  500
#> 360      1   0 13   312 Inf   lambda.z.n.points 7.000000e+00    <NA>  500
#> 361      1   0 13   312 Inf          clast.pred 5.460421e-05    <NA>  500
#> 362      1   0 13   312 Inf           half.life 7.691668e+00    <NA>  500
#> 363      1   0 13   312 Inf          span.ratio 2.028169e+01    <NA>  500
#> 364      1   0 13   312 Inf          aucinf.obs 1.865533e+04    <NA>  500
#> 365      1   0 14     0  24             auclast 1.358547e+04    <NA>  500
#> 366      1   0 14     0 Inf                cmax 4.489737e+03    <NA>  500
#> 367      1   0 14     0 Inf                tmax 1.000000e+00    <NA>  500
#> 368      1   0 14     0 Inf               tlast 1.680000e+02    <NA>  500
#> 369      1   0 14     0 Inf           clast.obs 4.390558e-05    <NA>  500
#> 370      1   0 14     0 Inf            lambda.z 8.757659e-02    <NA>  500
#> 371      1   0 14     0 Inf           r.squared 9.999866e-01    <NA>  500
#> 372      1   0 14     0 Inf       adj.r.squared 9.999832e-01    <NA>  500
#> 373      1   0 14     0 Inf lambda.z.time.first 2.400000e+01    <NA>  500
#> 374      1   0 14     0 Inf   lambda.z.n.points 6.000000e+00    <NA>  500
#> 375      1   0 14     0 Inf          clast.pred 4.445670e-05    <NA>  500
#> 376      1   0 14     0 Inf           half.life 7.914754e+00    <NA>  500
#> 377      1   0 14     0 Inf          span.ratio 1.819387e+01    <NA>  500
#> 378      1   0 14     0 Inf          aucinf.obs 1.373685e+04    <NA>  500
#> 379      0   0 14   312 336             auclast 2.069564e+04    <NA>  500
#> 380      0   0 14   312 Inf                cmax 3.629774e+03    <NA>  500
#> 381      0   0 14   312 Inf                tmax 2.000000e+00    <NA>  500
#> 382      0   0 14   312 Inf               tlast 1.680000e+02    <NA>  500
#> 383      0   0 14   312 Inf           clast.obs 8.703569e-05    <NA>  500
#> 384      0   0 14   312 Inf            lambda.z 8.736114e-02    <NA>  500
#> 385      0   0 14   312 Inf           r.squared 9.999756e-01    <NA>  500
#> 386      0   0 14   312 Inf       adj.r.squared 9.999674e-01    <NA>  500
#> 387      0   0 14   312 Inf lambda.z.time.first 4.800000e+01    <NA>  500
#> 388      0   0 14   312 Inf   lambda.z.n.points 5.000000e+00    <NA>  500
#> 389      0   0 14   312 Inf          clast.pred 8.925689e-05    <NA>  500
#> 390      0   0 14   312 Inf           half.life 7.934273e+00    <NA>  500
#> 391      0   0 14   312 Inf          span.ratio 1.512426e+01    <NA>  500
#> 392      0   0 14   312 Inf          aucinf.obs 2.106485e+04    <NA>  500
#> 393      0   0 15     0  24             auclast 4.705248e+04    <NA>  500
#> 394      0   0 15     0 Inf                cmax 6.801036e+03    <NA>  500
#> 395      0   0 15     0 Inf                tmax 3.000000e+00    <NA>  500
#> 396      0   0 15     0 Inf               tlast 1.680000e+02    <NA>  500
#> 397      0   0 15     0 Inf           clast.obs 1.637464e-04    <NA>  500
#> 398      0   0 15     0 Inf            lambda.z 9.299096e-02    <NA>  500
#> 399      0   0 15     0 Inf           r.squared 9.999320e-01    <NA>  500
#> 400      0   0 15     0 Inf       adj.r.squared 9.999093e-01    <NA>  500
#> 401      0   0 15     0 Inf lambda.z.time.first 4.800000e+01    <NA>  500
#> 402      0   0 15     0 Inf   lambda.z.n.points 5.000000e+00    <NA>  500
#> 403      0   0 15     0 Inf          clast.pred 1.585577e-04    <NA>  500
#> 404      0   0 15     0 Inf           half.life 7.453920e+00    <NA>  500
#> 405      0   0 15     0 Inf          span.ratio 1.609891e+01    <NA>  500
#> 406      0   0 15     0 Inf          aucinf.obs 4.832842e+04    <NA>  500
#> 407      1   0 15   312 336             auclast 3.544204e+04    <NA>  500
#> 408      1   0 15   312 Inf                cmax 9.339374e+03    <NA>  500
#> 409      1   0 15   312 Inf                tmax 1.500000e+00    <NA>  500
#> 410      1   0 15   312 Inf               tlast 1.680000e+02    <NA>  500
#> 411      1   0 15   312 Inf           clast.obs 8.553098e-05    <NA>  500
#> 412      1   0 15   312 Inf            lambda.z 9.361598e-02    <NA>  500
#> 413      1   0 15   312 Inf           r.squared 9.999500e-01    <NA>  500
#> 414      1   0 15   312 Inf       adj.r.squared 9.999400e-01    <NA>  500
#> 415      1   0 15   312 Inf lambda.z.time.first 1.200000e+01    <NA>  500
#> 416      1   0 15   312 Inf   lambda.z.n.points 7.000000e+00    <NA>  500
#> 417      1   0 15   312 Inf          clast.pred 8.298710e-05    <NA>  500
#> 418      1   0 15   312 Inf           half.life 7.404154e+00    <NA>  500
#> 419      1   0 15   312 Inf          span.ratio 2.106925e+01    <NA>  500
#> 420      1   0 15   312 Inf          aucinf.obs 3.605800e+04    <NA>  500
#> 421      1   0 16     0  24             auclast 1.964559e+04    <NA>  500
#> 422      1   0 16     0 Inf                cmax 5.547706e+03    <NA>  500
#> 423      1   0 16     0 Inf                tmax 1.500000e+00    <NA>  500
#> 424      1   0 16     0 Inf               tlast 1.680000e+02    <NA>  500
#> 425      1   0 16     0 Inf           clast.obs 6.351925e-05    <NA>  500
#> 426      1   0 16     0 Inf            lambda.z 8.924039e-02    <NA>  500
#> 427      1   0 16     0 Inf           r.squared 9.999894e-01    <NA>  500
#> 428      1   0 16     0 Inf       adj.r.squared 9.999867e-01    <NA>  500
#> 429      1   0 16     0 Inf lambda.z.time.first 2.400000e+01    <NA>  500
#> 430      1   0 16     0 Inf   lambda.z.n.points 6.000000e+00    <NA>  500
#> 431      1   0 16     0 Inf          clast.pred 6.301520e-05    <NA>  500
#> 432      1   0 16     0 Inf           half.life 7.767191e+00    <NA>  500
#> 433      1   0 16     0 Inf          span.ratio 1.853952e+01    <NA>  500
#> 434      1   0 16     0 Inf          aucinf.obs 1.991570e+04    <NA>  500
#> 435      0   0 16   312 336             auclast 2.697415e+04    <NA>  500
#> 436      0   0 16   312 Inf                cmax 4.161112e+03    <NA>  500
#> 437      0   0 16   312 Inf                tmax 3.000000e+00    <NA>  500
#> 438      0   0 16   312 Inf               tlast 1.680000e+02    <NA>  500
#> 439      0   0 16   312 Inf           clast.obs 1.123415e-04    <NA>  500
#> 440      0   0 16   312 Inf            lambda.z 8.996109e-02    <NA>  500
#> 441      0   0 16   312 Inf           r.squared 9.999979e-01    <NA>  500
#> 442      0   0 16   312 Inf       adj.r.squared 9.999972e-01    <NA>  500
#> 443      0   0 16   312 Inf lambda.z.time.first 4.800000e+01    <NA>  500
#> 444      0   0 16   312 Inf   lambda.z.n.points 5.000000e+00    <NA>  500
#> 445      0   0 16   312 Inf          clast.pred 1.130966e-04    <NA>  500
#> 446      0   0 16   312 Inf           half.life 7.704966e+00    <NA>  500
#> 447      0   0 16   312 Inf          span.ratio 1.557437e+01    <NA>  500
#> 448      0   0 16   312 Inf          aucinf.obs 2.762222e+04    <NA>  500
#> 449      1   0 17     0  24             auclast 1.982688e+04    <NA>  500
#> 450      1   0 17     0 Inf                cmax 5.447778e+03    <NA>  500
#> 451      1   0 17     0 Inf                tmax 1.500000e+00    <NA>  500
#> 452      1   0 17     0 Inf               tlast 1.680000e+02    <NA>  500
#> 453      1   0 17     0 Inf           clast.obs 4.083561e-05    <NA>  500
#> 454      1   0 17     0 Inf            lambda.z 9.207758e-02    <NA>  500
#> 455      1   0 17     0 Inf           r.squared 9.999516e-01    <NA>  500
#> 456      1   0 17     0 Inf       adj.r.squared 9.999395e-01    <NA>  500
#> 457      1   0 17     0 Inf lambda.z.time.first 2.400000e+01    <NA>  500
#> 458      1   0 17     0 Inf   lambda.z.n.points 6.000000e+00    <NA>  500
#> 459      1   0 17     0 Inf          clast.pred 4.030935e-05    <NA>  500
#> 460      1   0 17     0 Inf           half.life 7.527860e+00    <NA>  500
#> 461      1   0 17     0 Inf          span.ratio 1.912894e+01    <NA>  500
#> 462      1   0 17     0 Inf          aucinf.obs 2.007515e+04    <NA>  500
#> 463      0   0 17   312 336             auclast 2.838540e+04    <NA>  500
#> 464      0   0 17   312 Inf                cmax 4.650235e+03    <NA>  500
#> 465      0   0 17   312 Inf                tmax 2.000000e+00    <NA>  500
#> 466      0   0 17   312 Inf               tlast 1.680000e+02    <NA>  500
#> 467      0   0 17   312 Inf           clast.obs 7.862104e-05    <NA>  500
#> 468      0   0 17   312 Inf            lambda.z 9.176957e-02    <NA>  500
#> 469      0   0 17   312 Inf           r.squared 9.999844e-01    <NA>  500
#> 470      0   0 17   312 Inf       adj.r.squared 9.999793e-01    <NA>  500
#> 471      0   0 17   312 Inf lambda.z.time.first 4.800000e+01    <NA>  500
#> 472      0   0 17   312 Inf   lambda.z.n.points 5.000000e+00    <NA>  500
#> 473      0   0 17   312 Inf          clast.pred 7.926174e-05    <NA>  500
#> 474      0   0 17   312 Inf           half.life 7.553127e+00    <NA>  500
#> 475      0   0 17   312 Inf          span.ratio 1.588746e+01    <NA>  500
#> 476      0   0 17   312 Inf          aucinf.obs 2.897641e+04    <NA>  500
#> 477      1   0 18     0  24             auclast 2.631496e+04    <NA>  500
#> 478      1   0 18     0 Inf                cmax 6.407331e+03    <NA>  500
#> 479      1   0 18     0 Inf                tmax 1.500000e+00    <NA>  500
#> 480      1   0 18     0 Inf               tlast 1.680000e+02    <NA>  500
#> 481      1   0 18     0 Inf           clast.obs 6.838782e-06    <NA>  500
#> 482      1   0 18     0 Inf            lambda.z 1.073401e-01    <NA>  500
#> 483      1   0 18     0 Inf           r.squared 9.999576e-01    <NA>  500
#> 484      1   0 18     0 Inf       adj.r.squared 9.999470e-01    <NA>  500
#> 485      1   0 18     0 Inf lambda.z.time.first 2.400000e+01    <NA>  500
#> 486      1   0 18     0 Inf   lambda.z.n.points 6.000000e+00    <NA>  500
#> 487      1   0 18     0 Inf          clast.pred 6.510574e-06    <NA>  500
#> 488      1   0 18     0 Inf           half.life 6.457486e+00    <NA>  500
#> 489      1   0 18     0 Inf          span.ratio 2.229970e+01    <NA>  500
#> 490      1   0 18     0 Inf          aucinf.obs 2.663572e+04    <NA>  500
#> 491      0   0 18   312 336             auclast 3.539986e+04    <NA>  500
#> 492      0   0 18   312 Inf                cmax 4.499100e+03    <NA>  500
#> 493      0   0 18   312 Inf                tmax 2.000000e+00    <NA>  500
#> 494      0   0 18   312 Inf               tlast 1.680000e+02    <NA>  500
#> 495      0   0 18   312 Inf           clast.obs 1.581891e-05    <NA>  500
#> 496      0   0 18   312 Inf            lambda.z 1.078429e-01    <NA>  500
#> 497      0   0 18   312 Inf           r.squared 9.999480e-01    <NA>  500
#> 498      0   0 18   312 Inf       adj.r.squared 9.999307e-01    <NA>  500
#> 499      0   0 18   312 Inf lambda.z.time.first 4.800000e+01    <NA>  500
#> 500      0   0 18   312 Inf   lambda.z.n.points 5.000000e+00    <NA>  500
#> 501      0   0 18   312 Inf          clast.pred 1.580876e-05    <NA>  500
#> 502      0   0 18   312 Inf           half.life 6.427381e+00    <NA>  500
#> 503      0   0 18   312 Inf          span.ratio 1.867012e+01    <NA>  500
#> 504      0   0 18   312 Inf          aucinf.obs 3.657208e+04    <NA>  500
#> 505      0   1 19     0  24             auclast 2.461443e+04    <NA>  500
#> 506      0   1 19     0 Inf                cmax 3.516646e+03    <NA>  500
#> 507      0   1 19     0 Inf                tmax 3.000000e+00    <NA>  500
#> 508      0   1 19     0 Inf               tlast 1.680000e+02    <NA>  500
#> 509      0   1 19     0 Inf           clast.obs 1.120752e-03    <NA>  500
#> 510      0   1 19     0 Inf            lambda.z 7.252218e-02    <NA>  500
#> 511      0   1 19     0 Inf           r.squared 9.999962e-01    <NA>  500
#> 512      0   1 19     0 Inf       adj.r.squared 9.999924e-01    <NA>  500
#> 513      0   1 19     0 Inf lambda.z.time.first 9.600000e+01    <NA>  500
#> 514      0   1 19     0 Inf   lambda.z.n.points 3.000000e+00    <NA>  500
#> 515      0   1 19     0 Inf          clast.pred 1.125150e-03    <NA>  500
#> 516      0   1 19     0 Inf           half.life 9.557726e+00    <NA>  500
#> 517      0   1 19     0 Inf          span.ratio 7.533172e+00    <NA>  500
#> 518      0   1 19     0 Inf          aucinf.obs 2.532563e+04    <NA>  500
#> 519      1   1 19   312 336             auclast 1.697932e+04    <NA>  500
#> 520      1   1 19   312 Inf                cmax 4.588825e+03    <NA>  500
#> 521      1   1 19   312 Inf                tmax 1.500000e+00    <NA>  500
#> 522      1   1 19   312 Inf               tlast 1.680000e+02    <NA>  500
#> 523      1   1 19   312 Inf           clast.obs 6.157266e-04    <NA>  500
#> 524      1   1 19   312 Inf            lambda.z 7.320386e-02    <NA>  500
#> 525      1   1 19   312 Inf           r.squared 9.999732e-01    <NA>  500
#> 526      1   1 19   312 Inf       adj.r.squared 9.999664e-01    <NA>  500
#> 527      1   1 19   312 Inf lambda.z.time.first 2.400000e+01    <NA>  500
#> 528      1   1 19   312 Inf   lambda.z.n.points 6.000000e+00    <NA>  500
#> 529      1   1 19   312 Inf          clast.pred 6.078001e-04    <NA>  500
#> 530      1   1 19   312 Inf           half.life 9.468724e+00    <NA>  500
#> 531      1   1 19   312 Inf          span.ratio 1.520796e+01    <NA>  500
#> 532      1   1 19   312 Inf          aucinf.obs 1.729700e+04    <NA>  500
#> 533      1   0 20     0  24             auclast 1.365089e+04    <NA>  500
#> 534      1   0 20     0 Inf                cmax 4.126813e+03    <NA>  500
#> 535      1   0 20     0 Inf                tmax 1.000000e+00    <NA>  500
#> 536      1   0 20     0 Inf               tlast 1.680000e+02    <NA>  500
#> 537      1   0 20     0 Inf           clast.obs 3.322179e-06    <NA>  500
#> 538      1   0 20     0 Inf            lambda.z 1.064484e-01    <NA>  500
#> 539      1   0 20     0 Inf           r.squared 9.999136e-01    <NA>  500
#> 540      1   0 20     0 Inf       adj.r.squared 9.998963e-01    <NA>  500
#> 541      1   0 20     0 Inf lambda.z.time.first 1.200000e+01    <NA>  500
#> 542      1   0 20     0 Inf   lambda.z.n.points 7.000000e+00    <NA>  500
#> 543      1   0 20     0 Inf          clast.pred 3.193431e-06    <NA>  500
#> 544      1   0 20     0 Inf           half.life 6.511579e+00    <NA>  500
#> 545      1   0 20     0 Inf          span.ratio 2.395732e+01    <NA>  500
#> 546      1   0 20     0 Inf          aucinf.obs 1.378046e+04    <NA>  500
#> 547      0   0 20   312 336             auclast 2.050570e+04    <NA>  500
#> 548      0   0 20   312 Inf                cmax 3.358273e+03    <NA>  500
#> 549      0   0 20   312 Inf                tmax 2.000000e+00    <NA>  500
#> 550      0   0 20   312 Inf               tlast 1.680000e+02    <NA>  500
#> 551      0   0 20   312 Inf           clast.obs 7.391557e-06    <NA>  500
#> 552      0   0 20   312 Inf            lambda.z 1.061880e-01    <NA>  500
#> 553      0   0 20   312 Inf           r.squared 9.999752e-01    <NA>  500
#> 554      0   0 20   312 Inf       adj.r.squared 9.999670e-01    <NA>  500
#> 555      0   0 20   312 Inf lambda.z.time.first 4.800000e+01    <NA>  500
#> 556      0   0 20   312 Inf   lambda.z.n.points 5.000000e+00    <NA>  500
#> 557      0   0 20   312 Inf          clast.pred 7.244380e-06    <NA>  500
#> 558      0   0 20   312 Inf           half.life 6.527547e+00    <NA>  500
#> 559      0   0 20   312 Inf          span.ratio 1.838363e+01    <NA>  500
#> 560      0   0 20   312 Inf          aucinf.obs 2.087764e+04    <NA>  500