This function adds a column DI that indicates the dosing interval. All
baseline observations before the first dosing interval get assigned to the
first dosing interval, too. In addition to DI, the function also calls
index_nif(), thus creating the field REF as a side effect.
Examples
head(index_dosing_interval(examplinib_fe_nif))
#> REF ID STUDYID USUBJID AGE SEX RACE HEIGHT WEIGHT BMI
#> 1 1 1 2023000400 20230004001010002 53 1 WHITE 180.4 73.1 22.46179
#> 2 2 1 2023000400 20230004001010002 53 1 WHITE 180.4 73.1 22.46179
#> 3 3 1 2023000400 20230004001010002 53 1 WHITE 180.4 73.1 22.46179
#> 4 4 1 2023000400 20230004001010002 53 1 WHITE 180.4 73.1 22.46179
#> 5 5 1 2023000400 20230004001010002 53 1 WHITE 180.4 73.1 22.46179
#> 6 6 1 2023000400 20230004001010002 53 1 WHITE 180.4 73.1 22.46179
#> DTC TIME NTIME TAFD TAD PCELTM EVID AMT ANALYTE CMT PARENT
#> 1 2001-01-05 10:05:00 0.0 0.0 0.0 0.0 <NA> 1 500 RS2023 1 RS2023
#> 2 2001-01-05 10:05:00 0.0 0.0 0.0 0.0 PT0H 0 0 RS2023 2 RS2023
#> 3 2001-01-05 10:35:00 0.5 0.5 0.5 0.5 PT0.5H 0 0 RS2023 2 RS2023
#> 4 2001-01-05 11:05:00 1.0 1.0 1.0 1.0 PT1H 0 0 RS2023 2 RS2023
#> 5 2001-01-05 11:35:00 1.5 1.5 1.5 1.5 PT1.5H 0 0 RS2023 2 RS2023
#> 6 2001-01-05 12:05:00 2.0 2.0 2.0 2.0 PT2H 0 0 RS2023 2 RS2023
#> TRTDY METABOLITE DOSE MDV ACTARMCD IMPUTATION PERIOD
#> 1 1 FALSE 500 1 AB admin time imputed from PCRFTDTC 1
#> 2 1 FALSE 500 0 AB 1
#> 3 1 FALSE 500 0 AB 1
#> 4 1 FALSE 500 0 AB 1
#> 5 1 FALSE 500 0 AB 1
#> 6 1 FALSE 500 0 AB 1
#> FASTED DI TREATMENT DV EPOCH
#> 1 1 1 A NA OPEN LABEL TREATMENT 1
#> 2 1 1 A 0.000 OPEN LABEL TREATMENT 1
#> 3 1 1 A 4697.327 OPEN LABEL TREATMENT 1
#> 4 1 1 A 6325.101 OPEN LABEL TREATMENT 1
#> 5 1 1 A 6294.187 OPEN LABEL TREATMENT 1
#> 6 1 1 A 5932.464 OPEN LABEL TREATMENT 1
head(index_dosing_interval(examplinib_poc_nif))
#> REF ID STUDYID USUBJID AGE SEX RACE HEIGHT WEIGHT BMI
#> 1 1 1 2023000022 20230000221010001 58 1 WHITE 185.3 91.4 26.61922
#> 2 2 1 2023000022 20230000221010001 58 1 WHITE 185.3 91.4 26.61922
#> 3 3 1 2023000022 20230000221010001 58 1 WHITE 185.3 91.4 26.61922
#> 4 4 1 2023000022 20230000221010001 58 1 WHITE 185.3 91.4 26.61922
#> 5 5 1 2023000022 20230000221010001 58 1 WHITE 185.3 91.4 26.61922
#> 6 6 1 2023000022 20230000221010001 58 1 WHITE 185.3 91.4 26.61922
#> DTC TIME NTIME TAFD TAD PCELTM EVID AMT ANALYTE CMT
#> 1 2001-01-13 10:36:00 0.000 0.0 0.000 0.000 <NA> 1 500 RS2023 1
#> 2 2001-01-13 10:36:00 0.000 0.0 0.000 0.000 PT0H 0 0 RS2023 2
#> 3 2001-01-13 10:36:00 0.000 0.0 0.000 0.000 PT0H 0 0 RS2023487A 3
#> 4 2001-01-13 11:36:00 1.000 0.5 1.000 1.000 PT0.5H 0 0 RS2023 2
#> 5 2001-01-13 11:36:00 1.000 0.5 1.000 1.000 PT0.5H 0 0 RS2023487A 3
#> 6 2001-01-13 12:04:00 1.467 1.0 1.467 1.467 PT1H 0 0 RS2023 2
#> PARENT TRTDY METABOLITE DOSE MDV ACTARMCD IMPUTATION
#> 1 RS2023 1 FALSE 500 1 TREATMENT admin time imputed from PCRFTDTC
#> 2 RS2023 1 FALSE 500 0 TREATMENT
#> 3 RS2023 1 FALSE 500 0 TREATMENT
#> 4 RS2023 1 FALSE 500 0 TREATMENT
#> 5 RS2023 1 FALSE 500 0 TREATMENT
#> 6 RS2023 1 FALSE 500 0 TREATMENT
#> DI DV BL_CREAT BL_CRCL
#> 1 1 NA 72.78062 107.4689
#> 2 1 0.0000 72.78062 107.4689
#> 3 1 0.0000 72.78062 107.4689
#> 4 1 636.6833 72.78062 107.4689
#> 5 1 135.1259 72.78062 107.4689
#> 6 1 1844.8225 72.78062 107.4689
head(index_dosing_interval(examplinib_poc_min_nif))
#> REF ID TIME EVID AMT CMT PARENT MDV DI RATE DV
#> 1 1 1 0.000 1 500 1 1 1 1 0 NA
#> 2 2 1 0.000 0 0 2 1 0 1 0 0.000000
#> 3 3 1 0.000 0 0 3 1 0 1 0 0.000000
#> 4 4 1 2.167 0 0 2 1 0 1 0 3.380265
#> 5 5 1 2.167 0 0 3 1 0 1 0 3.453869
#> 6 6 1 4.633 0 0 2 1 0 1 0 1.477397