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Refer to the FDA guidance on DILI, https://www.fda.gov/media/116737/download and Watkins 2011, doi:10.2165/11586600-000000000-00000 .

Usage

edish_plot(
  nif,
  sdtm,
  enzyme = "ALT",
  observation_filter = NULL,
  baseline_filter = "LBBLFL == 'Y'",
  show_labels = FALSE,
  shading = TRUE,
  title = "eDISH plot",
  size = 3,
  alpha = 0.5,
  silent = NULL,
  ...
)

Arguments

nif

A nif object.

sdtm

A sdtm object.

enzyme

The transaminase enzyme to be plotted on the x axis as character, can be 'AST' or 'ALT' (default).

observation_filter

A filter term as character.

baseline_filter

A filter term to identify baseline conditions.

show_labels

Show ID labels per point.

shading

Highlight Hy's law area, as logical.

title

The plot title as character.

size

The point size as numeric.

alpha

The alpha value as numeric.

silent

Suppress messages.

...

Further graphical parameters.

Value

A ggplot object.