Refer to the FDA guidance on Drug-induced liver injury and Watkins 2011.
Usage
edish_plot(
nif,
sdtm,
enzyme = "ALT",
observation_filter = "LBSPEC != 'URINE'",
show_labels = FALSE,
autoscale = TRUE,
shading = TRUE,
nominal_time = TRUE,
ntime_method = NULL,
time = NULL,
parent = NULL,
title = "eDISH plot: All time points",
size = 3,
alpha = 0.5,
...
)Arguments
- nif
A nif object.
- sdtm
A sdtm object.
- enzyme
The transaminase enzyme to be plotted on the x axis as character, can be 'AST' or 'ALT' (default).
- observation_filter
A filter term as character.
- show_labels
Show ID labels per point.
- autoscale
Use automatic axis scaling, as logical. Defaults to 0.01-1000 for ALT/AST and 0.01-100 for bili.
- shading
Highlight Hy's law area, as logical.
- nominal_time
Use NTIME as logical.
- ntime_method
the field to derive the nominal time from. Allowed values are "TPT" and "ELTM".Defaults to xxTPT where xx is the domain name, if NULL.
- time
time/nominal time filter as numeric.
- parent
The parent compound as character.
- title
The plot title as character.
- size
The point size as numeric.
- alpha
The alpha value as numeric.
- ...
Further graphical parameters.