Dose level is defined as the starting dose. For data sets with single drug
administration, DLis a numerical value, for drug combinations, it is a
character value specifying the PARENT and dose level for the individual
components.
Examples
head(add_dose_level(examplinib_sad_nif))
#> REF ID STUDYID USUBJID AGE SEX RACE HEIGHT WEIGHT BMI
#> 1 1 1 2023000001 20230000011010001 43 0 WHITE 187.4 77 21.9256
#> 2 2 1 2023000001 20230000011010001 43 0 WHITE 187.4 77 21.9256
#> 3 3 1 2023000001 20230000011010001 43 0 WHITE 187.4 77 21.9256
#> 4 4 1 2023000001 20230000011010001 43 0 WHITE 187.4 77 21.9256
#> 5 5 1 2023000001 20230000011010001 43 0 WHITE 187.4 77 21.9256
#> 6 6 1 2023000001 20230000011010001 43 0 WHITE 187.4 77 21.9256
#> DTC TIME NTIME TAFD TAD PCELTM EVID AMT ANALYTE CMT PARENT
#> 1 2000-12-31 10:18:00 0.0 0.0 0.0 0.0 <NA> 1 5 RS2023 1 RS2023
#> 2 2000-12-31 10:18:00 0.0 0.0 0.0 0.0 PT0H 0 0 RS2023 2 RS2023
#> 3 2000-12-31 10:48:00 0.5 0.5 0.5 0.5 PT0.5H 0 0 RS2023 2 RS2023
#> 4 2000-12-31 11:18:00 1.0 1.0 1.0 1.0 PT1H 0 0 RS2023 2 RS2023
#> 5 2000-12-31 11:48:00 1.5 1.5 1.5 1.5 PT1.5H 0 0 RS2023 2 RS2023
#> 6 2000-12-31 12:18:00 2.0 2.0 2.0 2.0 PT2H 0 0 RS2023 2 RS2023
#> TRTDY METABOLITE DOSE DV MDV ACTARMCD IMPUTATION
#> 1 1 FALSE 5 NA 1 C1 admin time imputed from PCRFTDTC
#> 2 1 FALSE 5 0.0000 0 C1
#> 3 1 FALSE 5 40.7852 0 C1
#> 4 1 FALSE 5 48.5530 0 C1
#> 5 1 FALSE 5 44.0391 0 C1
#> 6 1 FALSE 5 34.0729 0 C1
#> BL_CREAT BL_CRCL DL
#> 1 67.4825 115.5074 5
#> 2 67.4825 115.5074 5
#> 3 67.4825 115.5074 5
#> 4 67.4825 115.5074 5
#> 5 67.4825 115.5074 5
#> 6 67.4825 115.5074 5
head(add_dose_level(examplinib_sad_min_nif))
#> ID TIME AMT RATE EVID DV CMT MDV DL
#> 1 1 0.0 5 0 1 NA 1 1 5
#> 2 1 0.0 0 0 0 0.0000000 2 0 5
#> 3 1 0.5 0 0 0 0.0024470 2 0 5
#> 4 1 1.0 0 0 0 0.0072445 2 0 5
#> 5 1 1.5 0 0 0 0.0157476 2 0 5
#> 6 1 2.0 0 0 0 0.0209229 2 0 5