Add baseline renal function class — add_bl

If baseline creatinine clearance (BL_CRCL) is not included in the input, it will be calculated first.

Usage

add_bl_renal(obj, method = egfr_cg, molar = FALSE)

Arguments

obj: A NIF object.
method: The function to calculate eGFR (CrCL) from serum creatinine.
molar: Use molar concentrations. Currently either: egfr_mdrd, egfr_cg or egfr_raynaud

Value

A NIF object.

Examples

head(add_bl_renal(examplinib_poc_nif), 5)
#>   REF ID    STUDYID           USUBJID AGE SEX  RACE HEIGHT WEIGHT      BMI
#> 1   1  1 2023000022 20230000221010001  81   0 WHITE  180.5   93.9 28.82114
#> 2   2  1 2023000022 20230000221010001  81   0 WHITE  180.5   93.9 28.82114
#> 3   3  1 2023000022 20230000221010001  81   0 WHITE  180.5   93.9 28.82114
#> 4   4  1 2023000022 20230000221010001  81   0 WHITE  180.5   93.9 28.82114
#> 5   5  1 2023000022 20230000221010001  81   0 WHITE  180.5   93.9 28.82114
#>                   DTC  TIME NTIME  TAFD   TAD EVID AMT    ANALYTE CMT PARENT
#> 1 2001-01-07 09:42:00 0.000   0.0 0.000 0.000    1 500     RS2023   1 RS2023
#> 2 2001-01-07 09:42:00 0.000   0.0 0.000 0.000    0   0     RS2023   2 RS2023
#> 3 2001-01-07 09:42:00 0.000   0.0 0.000 0.000    0   0 RS2023487A   3 RS2023
#> 4 2001-01-07 10:34:00 0.867   0.5 0.867 0.867    0   0     RS2023   2 RS2023
#> 5 2001-01-07 10:34:00 0.867   0.5 0.867 0.867    0   0 RS2023487A   3 RS2023
#>   TRTDY METABOLITE DOSE MDV  ACTARMCD IMPUTATION       DV BL_CREAT  BL_CRCL
#> 1     1      FALSE  500   1 TREATMENT                  NA 86.46559 78.66727
#> 2     1      FALSE  500   0 TREATMENT              0.0000 86.46559 78.66727
#> 3     1      FALSE  500   0 TREATMENT              0.0000 86.46559 78.66727
#> 4     1      FALSE  500   0 TREATMENT            615.0549 86.46559 78.66727
#> 5     1      FALSE  500   0 TREATMENT            120.1609 86.46559 78.66727
#>   BL_RENAL
#> 1     mild
#> 2     mild
#> 3     mild
#> 4     mild
#> 5     mild