Drug administration data is taken from the EX domain of the sdtm object. The 'extrt' field specifies the drug name as represented in 'EX', however, a different 'analyte' name can be assigned to match with that of the pharmacokinetic observations for the parent drug in plasma.
Usage
add_administration(
nif,
sdtm,
extrt,
analyte = NA,
cmt = 1,
subject_filter = "!ACTARMCD %in% c('SCRNFAIL', 'NOTTRT')",
cut_off_date = NULL,
keep = NULL,
debug = FALSE,
silent = NULL
)Arguments
- nif
A nif object.
- sdtm
A sdtm object.
- extrt
The EXTRT for the administration, as character.
- analyte
The name of the analyte as character.
- cmt
The compartment for the administration as numeric.
- subject_filter
The filtering to apply to the DM domain, as string,
- cut_off_date
The data cut-off date as Posix date-time.
- keep
Columns to keep after cleanup, as character.
- debug
Include debug fields, as logical.
- silent
Suppress messages, defaults to nif_option standard when NULL.
Examples
add_administration(new_nif(), examplinib_sad, "EXAMPLINIB")
#> ----- NONMEM input file (NIF) object -----
#> 0 observations from 48 subjects across 1 study
#> Analytes: EXAMPLINIB
#> 48 males (100%), 0 females (0%)
#>
#> Columns:
#> REF, ID, STUDYID, USUBJID, AGE, SEX, RACE, HEIGHT, WEIGHT, BMI, DTC, TIME,
#> NTIME, TAFD, TAD, EVID, AMT, ANALYTE, CMT, PARENT, TRTDY, METABOLITE, DOSE,
#> MDV, ACTARMCD, IMPUTATION, DV
#>
#> Data (selected columns):
#> ID NTIME TIME TAD ANALYTE EVID CMT AMT DOSE DV
#> 1 0 0 0 EXAMPLINIB 1 1 5 5 NA
#> 2 0 0 0 EXAMPLINIB 1 1 5 5 NA
#> 3 0 0 0 EXAMPLINIB 1 1 5 5 NA
#> 4 0 0 0 EXAMPLINIB 1 1 10 10 NA
#> 5 0 0 0 EXAMPLINIB 1 1 10 10 NA
#> 6 0 0 0 EXAMPLINIB 1 1 10 10 NA
#> 7 0 0 0 EXAMPLINIB 1 1 20 20 NA
#> 8 0 0 0 EXAMPLINIB 1 1 20 20 NA
#> 9 0 0 0 EXAMPLINIB 1 1 20 20 NA
#> 10 0 0 0 EXAMPLINIB 1 1 50 50 NA
#> 38 more rows