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Table of drug transporter inhibition risks

transporter_inhibition_risk_table.Rd

Table of drug transporter inhibition risks

Usage

transporter_inhibition_risk_table(
  perp,
  transporter_inh,
  transporter_ref = transporter_reference_data,
  na.rm = F,
  show_dose = FALSE
)

Arguments

perp

The perpetrator object.

transporter_inh

Transporter inhibition data as data frame. The following fields are expected:

  • 'name' The perpetrator compound name.

  • 'cyp' The UGT enzyme as (upper case) character.

  • 'ic50' The \(IC_{50}\) of the inhibition in μM.

  • 'source' Optional source information as character.

transporter_ref

Transporter reference data, see transporter_reference_data for details.

na.rm

Exclude rows with lacking \(IC_{50}\) data from the output, as logical.

show_dose

Show_dose Show perpetrator dose in table title, as logical. Defaults to FALSE.

Value

A markdown-formatted table.

See also

transporter_inhibition_risk()

Examples

transporter_inhibition_risk_table(examplinib_parent,
  examplinib_transporter_inhibition_data)
#> 
#> 
#> Table: Risk for drug transporter inhibition by examplinib
#> 
#> |transporter | $IC_{50}$|source    |      $R$| threshold|risk |
#> |:-----------|---------:|:---------|--------:|---------:|:----|
#> |Pgp_int     |      0.41|study 005 | 8912.391|     10.00|Yes  |
#> |Pgp_sys     |      0.41|study 005 |    0.402|      0.02|Yes  |
#> |BCRP_int    |      1.90|study 005 | 1923.200|     10.00|Yes  |
#> |BCRP_sys    |      1.90|study 005 |    0.087|      0.02|Yes  |
#> |OATP1B1     |    177.00|study 006 |    0.001|      0.10|No   |
#> |OATP1B3     |     35.00|study 006 |    0.006|      0.10|No   |
#> |OAT1        |    271.00|          |    0.001|      0.10|No   |
#> |OAT3        |    300.00|          |    0.001|      0.10|No   |
#> |BSEP        |     12.80|          |    0.013|      0.10|No   |
#> |OCT1        |      2.30|study 006 |       NA|        NA|     |
#> |OCT2        |     67.00|study 006 |    0.002|      0.10|No   |
#> |MATE1       |      3.60|study 006 |    0.046|      0.02|Yes  |
#> |MATE2k      |      1.10|study 006 |    0.150|      0.02|Yes  |
transporter_inhibition_risk_table(examplinib_compounds,
  examplinib_transporter_inhibition_data)
#> 
#> 
#> Table: Risk for drug transporter inhibition by examplinib
#> 
#> |transporter | $IC_{50}$|source    |      $R$| threshold|risk |
#> |:-----------|---------:|:---------|--------:|---------:|:----|
#> |Pgp_int     |      0.41|study 005 | 8912.391|     10.00|Yes  |
#> |Pgp_sys     |      0.41|study 005 |    0.402|      0.02|Yes  |
#> |BCRP_int    |      1.90|study 005 | 1923.200|     10.00|Yes  |
#> |BCRP_sys    |      1.90|study 005 |    0.087|      0.02|Yes  |
#> |OATP1B1     |    177.00|study 006 |    0.001|      0.10|No   |
#> |OATP1B3     |     35.00|study 006 |    0.006|      0.10|No   |
#> |OAT1        |    271.00|          |    0.001|      0.10|No   |
#> |OAT3        |    300.00|          |    0.001|      0.10|No   |
#> |BSEP        |     12.80|          |    0.013|      0.10|No   |
#> |OCT1        |      2.30|study 006 |       NA|        NA|     |
#> |OCT2        |     67.00|study 006 |    0.002|      0.10|No   |
#> |MATE1       |      3.60|study 006 |    0.046|      0.02|Yes  |
#> |MATE2k      |      1.10|study 006 |    0.150|      0.02|Yes  |
transporter_inhibition_risk_table(examplinib_compounds,
  examplinib_transporter_inhibition_data, show_dose = TRUE)
#> 
#> 
#> Table: Risk for drug transporter inhibition by examplinib (450 mg)
#> 
#> |transporter | $IC_{50}$|source    |      $R$| threshold|risk |
#> |:-----------|---------:|:---------|--------:|---------:|:----|
#> |Pgp_int     |      0.41|study 005 | 8912.391|     10.00|Yes  |
#> |Pgp_sys     |      0.41|study 005 |    0.402|      0.02|Yes  |
#> |BCRP_int    |      1.90|study 005 | 1923.200|     10.00|Yes  |
#> |BCRP_sys    |      1.90|study 005 |    0.087|      0.02|Yes  |
#> |OATP1B1     |    177.00|study 006 |    0.001|      0.10|No   |
#> |OATP1B3     |     35.00|study 006 |    0.006|      0.10|No   |
#> |OAT1        |    271.00|          |    0.001|      0.10|No   |
#> |OAT3        |    300.00|          |    0.001|      0.10|No   |
#> |BSEP        |     12.80|          |    0.013|      0.10|No   |
#> |OCT1        |      2.30|study 006 |       NA|        NA|     |
#> |OCT2        |     67.00|study 006 |    0.002|      0.10|No   |
#> |MATE1       |      3.60|study 006 |    0.046|      0.02|Yes  |
#> |MATE2k      |      1.10|study 006 |    0.150|      0.02|Yes  |