Drug transporter reference data

Drug transporter reference data

Usage

transporter_reference_data

Format

• 'transporter' The name of the drug transporter protein.

• 'threshold' The regulatory threshold for clinically relevant interactions.

• 'i' The precipitant concentration metric applicable for the interaction.

Source

Section 2 of the ICH M12 guideline.

Details

transporter , threshold , i
Pgp_int     , 10        , igut
Pgp_sys     , 0.02      , imaxssu
BCRP_int    , 10        , igut
BCRP_sys    , 0.02      , imaxssu
OATP1B1     , 0.1       , imaxinletu
OATP1B3     , 0.1       , imaxinletu
OAT1        , 0.1       , imaxssu
OAT3        , 0.1       , imaxssu
BSEP        , 0.1       , imaxssu
OCT2        , 0.1       , imaxssu
MATE1       , 0.02      , imaxssu
MATE2k      , 0.02      , imaxssu

See also

key_concentrations()

transporter_inhibition_risk()