Summary statement for transporter inhibition

Usage

transporter_inhibition_risk_summary(
  perp,
  transporter_inh,
  transporter_ref = transporter_reference_data
)

Arguments

perp

The perpetrator object.

transporter_inh

Transporter inhibition data as data frame. The following fields are expected:

'name' The perpetrator compound name.
'cyp' The UGT enzyme as (upper case) character.
'ic50' The \(IC_{50}\) of the inhibition in μM.
'source' Optional source information as character.

transporter_ref

Transporter reference data, see transporter_reference_data for details.

Value

Markdown-formatted text output.

Examples

transporter_inhibition_risk_summary(examplinib_parent,
  examplinib_transporter_inhibition_data)
#> [1] "* examplinib has a clinical risk for inhibition of P-gp (intestinal), P-gp (hepatic), BCRP (intestinal), BCRP (hepatic), MATE1 and MATE2k"
transporter_inhibition_risk_summary(examplinib_metabolite,
  examplinib_transporter_inhibition_data)
#> NULL
transporter_inhibition_risk_summary(examplinib_compounds,
  examplinib_transporter_inhibition_data)
#> [1] "* examplinib has a clinical risk for inhibition of P-gp (intestinal), P-gp (hepatic), BCRP (intestinal), BCRP (hepatic), MATE1 and MATE2k"