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Hepatic CYP turnover data based on various publications

hepatic_cyp_turnover.Rd

[Deprecated]

Please use cyp_turnover instead.

Usage

hepatic_cyp_turnover

Format

A data frame with 6 columns:

  • cyp: The CYP enzymne

  • method: The experimental method used (below)

  • mean_hl: The mean CYP degradation half-life measured,

  • in_vivo: Study was conducted in vivo

  • reference: The source publication (PMID or DOI)

  • kdeg: The CYP degradation constant, i.e., \(log(2)/mean half-life\).

Source

This data set is taken from:

Yang J, Liao M, Shou M, Jamei M, Yeo KR, Tucker GT, Rostami-Hodjegan A. Cytochrome p450 turnover: regulation of synthesis and degradation, methods for determining rates, and implications for the prediction of drug interactions. Curr Drug Metab. 2008 Jun;9(5):384-94. doi: 10.2174/138920008784746382. PMID: 18537575.

Details

The following experimental methods were used in the original publication:

  • in vitro method 1: Radio-labeling of enzyme (‘pulse-chase’ method)

  • in vitro method 2: Degradation of enzyme in cultured hepatocytes or liver slices

  • in vivo method 1: Recovery of enzyme activity after enzyme induction

  • in vivo method 2: Recovery of enzyme activity after mechanism-based inhibition (MBI)

  • in vivo method 3: Pharmacokinetic modeling of auto-induction

These are the first few lines of the data frame:


   cyp            method mean_hl in_vivo                       reference   kdeg
CYP1A2 In vitro Method 1      51   FALSE                   PMID: 2136526 0.0136
CYP1A2 In vitro Method 2      43   FALSE   DOI: 10.1007/3-540-29804-5_25 0.0161
CYP1A2 In vitro Method 2      36   FALSE                  PMID: 10997941 0.0193
CYP1A2  In vivo Method 1      39    TRUE DOI: 10.1016/j.clpt.2004.04.003 0.0178
CYP1A2  In vivo Method 3     105    TRUE    DOI: 10.1038/sj.clpt.6100431 0.0066
CYP2A6 In vitro Method 2     226   FALSE                  PMID: 10997941 0.0031