CYP reference substrate data

CYP reference substrates commonly used in the mechanistic static assessment of the CYP DDI potential of drugs.

Usage

cyp_reference_substrates

Format

An object of class tbl_df (inherits from tbl, data.frame) with 6 rows and 5 columns.

Source

FDA and EMA guidelines.

Details

The CYP reference substrates currently implemented include:

cyp     , substrate   , fgut , fm   , fmcyp
CYP1A2  , tizanidine  , 1    , 0.95 , 0.98
CYP2C8  , repaglinide , 1    , 1    , 0.61
CYP2C9  , S-warfarin  , 1    , 1    , 0.91
CYP2C19 , omeprazole  , 1    , 1    , 0.87
CYP3A4  , midazolam   , 0.57 , 0.96 , 1

See also

mech_stat_cyp_risk()