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Basic CYP inhibition risk table

basic_cyp_inhibition_risk_table.Rd

This function generates a markdown-formatted table of the direct (reversible) CYP inhibition risk assessment. See basic_cyp_inhibition_risk() for details on the calculation of the risk.

Usage

basic_cyp_inhibition_risk_table(
  perp,
  cyp_inh,
  na.rm = FALSE,
  show_dose = FALSE
)

Arguments

perp

The perpetrator object.

cyp_inh

CYP inhibition data as data frame. The following fields are expected:

  • 'name' The name of the perpetrator compound.

  • 'cyp' The CYP enzyme as (upper case) character.

  • 'ki' The \(K_i\) in \(\mu M\) as numeric.

  • 'source' Optional source information as character.

na.rm

Switch to define whether rows with lacking \(K_i\) data are removed from the output (i.e., where ki == NA). Defaults to FALSE.

show_dose

Show perpetrator dose in table title, defaults to FALSE.

Value

A markdown-formatted table, or an empty string.

See also

basic_cyp_inhibition_risk()

Examples

basic_cyp_inhibition_risk_table(examplinib_parent,
  examplinib_cyp_inhibition_data)
#> 
#> 
#> Table: Risk for direct CYP inhibition by examplinib, basic model
#> 
#> |CYP     | $K_{i}$ ($\mu M$)| $K_{i,u}$ ($\mu M$)|   $R$|risk (hepatic) |$R_{gut}$ |risk (intestinal) |
#> |:-------|-----------------:|-------------------:|-----:|:--------------|:---------|:-----------------|
#> |CYP1A2  |                NA|                  NA|    NA|               |          |                  |
#> |CYP2B6  |                NA|                  NA|    NA|               |          |                  |
#> |CYP2C8  |             11.00|               11.00| 0.015|No             |          |                  |
#> |CYP2C9  |              0.60|                0.60| 0.275|Yes            |          |                  |
#> |CYP2C19 |              0.25|                0.25| 0.659|Yes            |          |                  |
#> |CYP2D6  |                NA|                  NA|    NA|               |          |                  |
#> |CYP3A4  |             12.50|               12.50| 0.013|No             |292.3     |Yes               |
basic_cyp_inhibition_risk_table(examplinib_compounds,
  examplinib_cyp_inhibition_data, na.rm = TRUE)
#> 
#> 
#> Table: Risk for direct CYP inhibition by examplinib, basic model
#> 
#> |CYP     | $K_{i}$ ($\mu M$)| $K_{i,u}$ ($\mu M$)|   $R$|risk (hepatic) |$R_{gut}$ |risk (intestinal) |
#> |:-------|-----------------:|-------------------:|-----:|:--------------|:---------|:-----------------|
#> |CYP2C8  |             11.00|               11.00| 0.015|No             |          |                  |
#> |CYP2C9  |              0.60|                0.60| 0.275|Yes            |          |                  |
#> |CYP2C19 |              0.25|                0.25| 0.659|Yes            |          |                  |
#> |CYP3A4  |             12.50|               12.50| 0.013|No             |292.3     |Yes               |
#> 
#> 
#> Table: Risk for direct CYP inhibition by M1, basic model
#> 
#> |CYP    | $K_{i}$ ($\mu M$)| $K_{i,u}$ ($\mu M$)|   $R$|risk (hepatic) |$R_{gut}$ |risk (intestinal) |
#> |:------|-----------------:|-------------------:|-----:|:--------------|:---------|:-----------------|
#> |CYP2C9 |               4.4|                 4.4| 0.006|No             |          |                  |
basic_cyp_inhibition_risk_table(examplinib_compounds,
  examplinib_cyp_inhibition_data, na.rm = TRUE, show_dose = TRUE)
#> 
#> 
#> Table: Risk for direct CYP inhibition by examplinib (450 mg), basic model
#> 
#> |CYP     | $K_{i}$ ($\mu M$)| $K_{i,u}$ ($\mu M$)|   $R$|risk (hepatic) |$R_{gut}$ |risk (intestinal) |
#> |:-------|-----------------:|-------------------:|-----:|:--------------|:---------|:-----------------|
#> |CYP2C8  |             11.00|               11.00| 0.015|No             |          |                  |
#> |CYP2C9  |              0.60|                0.60| 0.275|Yes            |          |                  |
#> |CYP2C19 |              0.25|                0.25| 0.659|Yes            |          |                  |
#> |CYP3A4  |             12.50|               12.50| 0.013|No             |292.3     |Yes               |
#> 
#> 
#> Table: Risk for direct CYP inhibition by M1, basic model
#> 
#> |CYP    | $K_{i}$ ($\mu M$)| $K_{i,u}$ ($\mu M$)|   $R$|risk (hepatic) |$R_{gut}$ |risk (intestinal) |
#> |:------|-----------------:|-------------------:|-----:|:--------------|:---------|:-----------------|
#> |CYP2C9 |               4.4|                 4.4| 0.006|No             |          |                  |